Change can be exciting, frustrating, challenging, disruptive, refreshing and overwhelming. And as illustrated by the COVID-19 pandemic, it can be abrupt and unexpected. The present challenges to creating safe workspaces, hospitality venues, educational spaces and senior living communities are daunting. Social connections and the use of shared and public spaces are confined to the parameters of social distancing guidelines. However, the renewed focus on healthy environments and infection control may also yield positive COVID-19 design impacts on commercial interior design. Our interior designers share their professional perspectives regarding COVID-19 design impacts, the current realities and anticipated lasting changes.